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Gene : AT3G07930 A. thaliana

DB identifier  ? AT3G07930 Secondary Identifier  ? locus:2077357
Brief Description  DNA glycosylase superfamily protein
TAIR Computational Description  DNA glycosylase superfamily protein;(source:Araport11)
TAIR Curator Summary  Encodes a DNA glycosylase that improves tolerance to genotoxic stress. MBD4L contains an exitron whose alternative splicing is regulated by heat stress and determines the enzyme destination (nucleoplasm/nucleolus).
TAIR Short Description  DNA glycosylase superfamily protein
TAIR Aliases  MBD4L

0 Gene Rifs

1 Organism

8 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 2127  
Location: Chr3:2526513-2528639

Gene models - AT3G07930 AT3G07930

? Gene models

Transcripts: 4  Exons: 9  Introns: 5 

Overlapping Features

? Genome features that overlap coordinates of this Gene

12 Child Features

0 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
MBD4L_ARATH-5 MBD4L_ARATH-2 MBD4L_ARATH MBD4L_ARATH-4 MBD4L_ARATH-3 function Monofunctional DNA glycosylase targeting U:G and T:G mispairs (PubMed:23994068). Excises uracil derivatives and exhibits a preference for a CpG sequence context, irrespective of the methylation status of the complementary strand (PubMed:23994068). The activity follows a biphasic kinetics, with an initial burst of product accumulation followed by a slower phase (PubMed:23994068). Specifically binds its reaction product (PubMed:23994068). Triggers the base excision repair (BER) pathway (PubMed:25900572).
MBD4L_ARATH-5 MBD4L_ARATH-2 MBD4L_ARATH MBD4L_ARATH-4 MBD4L_ARATH-3 tissue specificity Isoform 1 and isoform 4: Expressed in leaves and flowers, but not in roots or stems.

5 Proteins

Function

Gene Ontology

cellular component
nucleus  ? ECO  
molecular function
DNA binding  ? ECO  
hydrolase activity  ? ECO  
biological process
DNA repair  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

6 Data Sets