| Description | The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [ , ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars.The general mechanism of the PTS is the following: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred via a signal transduction pathway, to enzyme I (EI) which in turn transfers it to a phosphoryl carrier, the histidine protein (HPr). Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease, a membrane-bound complex known as enzyme 2 (EII), which transports the sugar to the cell. EII consists of at least three structurally distinct domains IIA, IIB and IIC [ ]. These can either be fused together in a single polypeptide chain or exist as two or three interactive chains, formerly called enzymes II (EII) and III (EIII).According to sequence analyses [ , , ], the PTS EIIC domain can be divided in five groups:The PTS EIIC type 1 domain is found in the Glucose class of PTS and has an average length of about 80 amino acids.The PTS EIIC type 2 domain is found in the Mannitol class of PTS and has an average length of about 90 amino acids.The PTS EIIC type 3 domain is found in the Lactose class of PTS and has an average length of about 100 amino acids.The PTS EIIC type 4 domain is found in the Mannose class of PTS and has an average length of about 160 amino acids.The PTS EIIC type 5 domain is found in the Sorbitol class of PTS and has an average length of about 190 amino acids.This entry represents the type 2 domain. | Name | Phosphotransferase system, EIIC component, type 2 |
| Short Name | PTS_EIIC_2 | Type | Domain |
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