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Gene : CAD1 A. thaliana

DB identifier	AT1G29690	Secondary Identifier	locus:2013673
Name	constitutively activated cell death 1	Brief Description	MAC/Perforin domain-containing protein

TAIR Computational Description	MAC/Perforin domain-containing protein;(source:Araport11)
TAIR Curator Summary	Encodes a protein containing a domain with significant homology to the MACPF (membrane attack complex and perforin) domain of complements and perforin proteins that are involved in innate immunity in animals. Transgenic <i>cad1-1</i> mutant plants show lesions seen in the hypersensitive response, as well as a spontaneous activation of expression of pathogenesis-related genes and leading to a 32-fold increase in salicylic acid (SA). CAD1 is postulated to act as a negative regulator controlling SA-mediated pathway of programmed cell death in plant immunity.
TAIR Short Description	MAC/Perforin domain-containing protein
TAIR Aliases	CAD1, NSL2

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1 Organism

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11 Publications

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0 Synonyms

Genomics

Genome feature

Region:	gene	Length:	3134
Location:	Chr1:10379020-10382153 reverse strand

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7 Child Features

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1 Cross References

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1 Downstream Intergenic Region

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0 Located Features

1 Upstream Intergenic Region

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Proteins

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Curated comments from UniProt

Type	Comment	Proteins
CAD1_ARATH	function	Negatively controls the salicylic acid (SA)-mediated pathway of programmed cell death in plant immunity.
CAD1_ARATH	similarity	Belongs to the complement C6/C7/C8/C9 (TC 1.C.39) family.
CAD1_ARATH	tissue specificity	Mainly expressed in the vascular system.

1 Proteins

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Function

Gene Ontology

cellular component
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molecular function
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biological process
immune response	ECO
plant-type hypersensitive response	ECO
regulation of salicylic acid metabolic process	ECO
regulation of salicylic acid mediated signaling pathway	ECO
cell death	ECO

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Expression

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Querying ATTED Service... Data Source: ATTED-II

Homology

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7 Data Sets

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