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Gene : TGH A. thaliana

DB identifier  ? AT5G23080 Secondary Identifier  ? locus:2178302
Name  ? TOUGH Brief Description  SWAP (Suppressor-of-White-APricot)/surp domain-containing protein
TAIR Computational Description  SWAP (Suppressor-of-White-APricot)/surp domain-containing protein;(source:Araport11)
TAIR Curator Summary  Interacts with TATA-box binding protein 2. Contains domains with strong similarity to G-patch and SWAP domains, characteristic of RNA binding and processing proteins. Colocalizes with the splicing regulator SRp34 to subnuclear particles. It is an important component of miRNA and siRNA biogenesis. Mutants display developmental defects, including reduced plant height, polycotyly, and reduced vascularization. Strong genetic interaction between TGH and AMP1. The stability of TGH transcript was maintained by ac4C modification.TGH tanscript is highly acetylated in Arabidopsis.
TAIR Short Description  SWAP (Suppressor-of-White-APricot)/surp domain-containing protein
TAIR Aliases  TGH

2 Gene Rifs

Trail: Gene

1 Organism

Trail: Gene

11 Publications

Trail: Gene

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 6081  
Location: Chr5:7742940-7749020 reverse strand

Gene models - TGH AT5G23080

? Gene models

Transcripts: 2  Exons: 31  Introns: 29 

Overlapping Features

? Genome features that overlap coordinates of this Gene

20 Child Features

Trail: Gene

0 Cross References

0 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Trail: Gene

Proteins

Curated comments from UniProt

Type Comment Proteins
TGH_ARATH TGH_ARATH-2 function Functions as a component of microRNA (miRNA) and small interfering RNA (siRNA) biogenesis. May assist DCL1 and DCL4 to efficiently process and/or recruit the precursors of miRNAs and siRNAs. In the miRNA biogenesis pathway, associates with the DCL1 complex that processes primary miRNAs (pri-miRNAs) into miRNAs. Binds pri-miRNAs and precursor miRNAs (pre-miRNAs). Is required for the interaction between pri-miRNAs and DRB1 (PubMed:22802657). Required for general proper plant growth and, in particular, initiation of vascular development. Interacts genetically with AMP1, a glutamate carboxypeptidase involved in the regulation of meristem function (PubMed:16024589).
TGH_ARATH TGH_ARATH-2 subcellular location Colocalizes with the splicing factor SR34 to subnuclear particles.
TGH_ARATH TGH_ARATH-2 tissue specificity Expressed in vasculature of cotyledons and leaves, young meristematic tissues, trichomes and pistils.

2 Proteins

Trail: Gene

Function

Gene Ontology

cellular component
nucleus  ? ECO  
nuclear speck  ? ECO  
molecular function
primary miRNA binding  ? ECO  
pre-miRNA binding  ? ECO  
RNA binding  ? ECO  
biological process
mRNA processing  ? ECO  
miRNA processing  ? ECO  
siRNA processing  ? ECO  
RNA processing  ? ECO  
phloem or xylem histogenesis  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

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Data Source: ATTED-II
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Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

8 Data Sets

Trail: Gene