Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
JMJ24_ARATH JMJ24_ARATH-2 | function | Binds histone H3 but seems to have lost demethylase activity probably due to its inability to bind iron Fe(2+) (PubMed:26979329). Possesses E3 ubiquitin ligase activity and targets directly CMT3 for proteasomal degradation to initiate destabilization of the heterochromatic state (e.g. CHG cytosine methylation and H3K9me2) of endogenous silenced loci (PubMed:26798133, PubMed:26979329). Required for the removal of repressive H3K9me2 histone marks to facilitate the transcription of AtSN1, AtMu1c, solo LTR and SDC, thus counteracting their transcriptional silencing (PubMed:26119694, PubMed:26979329). Mainly required to promote the basal level transcription of silenced loci such as TE and repeats targeted by RNA-dependent DNA methylation (RdDM) for silencing, a specialized branch of the RNA interference (RNAi) pathway (PubMed:26119694, PubMed:26979329, PubMed:28400174). Cooperates also with RNAi pathways for gene silencing both by contributing to the production of 24-nt siRNA to initiate RdDM and by recruiting RDR2 to enable local transcripts to make dsRNA (PubMed:26119694, PubMed:28400174). Antagonizes histone H3K9 demethylase IBM1/JMJ25 function (PubMed:28400174). |
JMJ24_ARATH JMJ24_ARATH-2 | similarity | Belongs to the JARID1 histone demethylase family. |
JMJ24_ARATH JMJ24_ARATH-2 | tissue specificity | Expressed in inflorescences, flowers, roots, siliques, leaves and stems, especially in the vasculature (mainly phloem), with highest levels in floral organs. |
Function
Gene Ontology
cellular component | |
---|---|
Set1C/COMPASS complex | ECO |
Ino80 complex | ECO |
nucleus | ECO |
molecular function | |
ubiquitin protein ligase activity | ECO |
ubiquitin conjugating enzyme binding | ECO |
histone binding | ECO |
transcription cis-regulatory region binding | ECO |
protein homodimerization activity | ECO |
metal ion binding | ECO |
biological process | |
positive regulation of gene expression | ECO |
heterochromatin formation | ECO |
negative regulation of DNA methylation-dependent heterochromatin formation | ECO |
regulation of regulatory ncRNA processing | ECO |
proteasome-mediated ubiquitin-dependent protein catabolic process | ECO |