Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
JMJ16_ARATH | developmental stage | Fades out gradually during aging. |
JMJ16_ARATH | function | Functions as a histone H3 'Lys-4' (H3K4me) demethylase involved in the negative regulation of gene expression (PubMed:30712008, PubMed:32572214). Active on H3K4me1, H3K4me2 and H3K4me3 (PubMed:30712008, PubMed:32572214). Not active on mono-, di- and trimethylated H3K9, H3K27 and H3K36 in somatic cells (PubMed:30712008, PubMed:32572214). However, also active on H3K9 when in complex with MMD1, a meiocyte-specific histone reader (PubMed:32572214). Together with MMD1, promotes gene expression in male meiocytes in an H3K9me3-dependent manner, and contributes to meiotic chromosome condensation by triggering some condensin promoters (e.g. CAP-D3 and CAP-H) (PubMed:32572214). Together with JMJ14 and JMJ17, required for plant growth and development (PubMed:31038749). Represses leaf senescence in an age-dependent manner by demethylating H3K4me3 activating histone marks at senescence-associated genes (SAGs) loci, including WRKY53 and SAG201, thus preventing their premature expression (PubMed:30712008). |
JMJ16_ARATH | similarity | Belongs to the JARID1 histone demethylase family. |
JMJ16_ARATH | tissue specificity | Confined to inflorescences. |
Function
Gene Ontology
cellular component | |
---|---|
nucleus | ECO |
molecular function | |
histone H3K4me/H3K4me2/H3K4me3 demethylase activity | ECO |
SUMO binding | ECO |
histone H3K9 demethylase activity | ECO |
metal ion binding | ECO |
biological process | |
developmental growth | ECO |
negative regulation of leaf senescence | ECO |
positive regulation of chromosome condensation | ECO |
positive regulation of gene expression | ECO |
regulation of DNA-templated transcription | ECO |
reactive oxygen species biosynthetic process | ECO |
negative regulation of gene expression, epigenetic | ECO |
plant organ development | ECO |
chromatin remodeling | ECO |
meiotic chromosome condensation | ECO |
Interactions
Interaction Network
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