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Gene : PEX5 A. thaliana

DB identifier  ? AT5G56290 Secondary Identifier  ? locus:2177606
Name  ? peroxin 5 Brief Description  peroxin 5
TAIR Computational Description  peroxin 5;(source:Araport11)
TAIR Curator Summary  Encodes the peroxisomal targeting signal type 1 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS1 consensus sequence (tripeptide SKL or a conserved variant) at the extreme C terminus. The protein has several domains, including C-terminal tetratricopeptide repeat motifs which act in binding the C-terminal "SKL" targeting signal. The mechanism of transport has been worked out in other organisms: The receptor recognizes and binds cytosolic PTS1-containing proteins. The PEX5-PTS1 complex binds a PEX14/PEX13 receptor complex at the peroxisome membrane and is translocated into the peroxisome matrix in a process dependent on PEX2,PEX10, and PEX12. In the peroxisome matrix, PEX5 releases its cargo and is recycled to the cytosol in a process dependent on PEX1, PEX4, PEX6 and PEX22. It is also involved, in conjunction with PEX7, in PTS1- and PTS2-dependent peroxisomal protein import. RNAi experiments suggest that PEX5 is necessary for the maintenance of both glyoxysomal and leaf peroxisomal functions.
TAIR Short Description  peroxin 5
TAIR Aliases  ATPEX5, EMB2790, PEX5

10 Gene Rifs

1 Organism

38 Publications

0 Synonyms


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16 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region


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1 Proteins


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9 Data Sets