Annotation | Study shows that in Arabidopsis non-CG methylation in CTCTGYTY motifs is one way to prevent REF6 targeting. Structural analysis demonstrates that CHG methylation is unfavorable for REF6 binding and attenuates REF6-binding affinity. Results reveal a mechanism for a transcriptional-activating histone-modifying enzyme in avoiding heterochromatic binding through its intrinsic DNA methylation unfavorable DNA-binding activity. | Organism | A. thaliana |
Gene | REF6 | PubMed Id | 31048693 |
last updated | 2019-06-15 |