| Description | This entry represents a group of alternative NADH:quinone oxidoreductases (also known as NDH-2) that deliver electrons to the respiratory chain by oxidation of NADH and reduction of quinones but does not pump protons [ ]. NDH-2 have particular relevance in yeasts like Saccharomyces cerevisiae and in several prokaryotes, whose respiratory chains are devoid of complex I, in which NDH-2 keep the balance and are the main entry point of electrons into the respiratory chains []. Structures of NDH-2 from the yeast Saccharomyces cerevisiae, also called Ndi1 (and ), and those from bacteria, Caldalkalibacillus thermarum ( ) and Staphylococcus aureus ( ), have been determined [ ]. Interestingly, since NDH-2s are present only in bacteria and certain plant, fungal and protozoan mitochondria, but not in mammals, they have been used as an drug target for Mycoplasma tuberculosis, Plasmodium falciparum and Toxoplasma gondii []. | Name | Alternative NADH dehydrogenase |
| Short Name | NDH-2 | Type | Family |
Powered by
Have you tried our InterMine mobile apps?
and interoperation is funded by 
