| Description | This is a family of closely related high pH (HPH) proteins that are integral endoplasmic reticulum (ER) membrane proteins required for yeast survival under environmental stress conditions [ ]. They interact with several subunits of the Sec63/Sec62 complex that mediates post-translational translocation of proteins into the ER []. Cells with mutant Hph1 and Hph2 proteins reveal phenotypes resembling those of mutants defective for vacuolar proton ATPase (V-ATPase) activity. The yeast V-ATPase is a multisubunit complex whose function, structure, and assembly have been well characterised. Cells with impaired V-ATPase activity fail to acidify the vacuole, cannot grow at alkaline pH, and are sensitive to high concentrations of extracellular calcium. | Name | High pH protein family |
| Short Name | HPH_family | Type | Family |
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