| Description | This domain contains regions binding additional 4Fe4S clusters found in various radical SAM proteins C-terminal to the domain described by . Radical SAM enzymes with this domain tend to be involved in protein modification, including anaerobic sulphatase maturation proteins, a quinohemoprotein amine dehydrogenase biogenesis protein, the Pep1357-cyclizing radical SAM enzyme, and various bacteriocin biosynthesis proteins [, ]. SkfB fromBacillus subtilis, which catalyses the formation of the thioether bond required for production of the sporulation killing factor SkfA [ ], also contains this domain. The motif CxxCxxxxxCxxxC is nearly invariant for members of this family, although PqqE has a variant form. This domain has been named SPASM for Subtilosin, PQQ, Anaerobic Sulphatase, and Mycofactocin. | Name | 4Fe4S-binding SPASM domain |
| Short Name | 4Fe4S-binding_SPASM_dom | Type | Domain |
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