| Description | This entry represents the N-terminal domain of prolyl 3,4-dihydroxylase Ofd1 from Schizosaccharomyces pombe and homologues in S. cerevisiae (TPA1) and mammals (OGFOD1) [ ].Ofd1 is a prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase that accelerates the degradation of Sre1N (the N-terminal transcription factor domain of Sre1) in the presence of oxygen [ ]. Yeast Sre1 is the orthologue of mammalian sterol regulatory element binding protein (SREBP), and it responds to changes in oxygen-dependent sterol synthesis as an indirect measure of oxygen availability. However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and this Ofd1 C-terminal domain accelerates Sre1N degradation in yeasts [, ]. | Name | Prolyl 3,4-dihydroxylase TPA1/OFD1, N-terminal domain |
| Short Name | TPA1/OFD1_N | Type | Domain |
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