Description | This family consists of several bacterial isocitrate dehydrogenase kinase/phosphatase (ICDH kinase/phosphatase) proteins. The enzyme has no activating compound but is specific for its substrate. It is a bifunctional enzyme that catalyses the reversible phosphorylation of isocitrate dehydrogenase (IDH, ) on a seryl residue. It consequently belongs to the serine/threonine protein kinase family [ ], and it acts in the Krebs cycle []. The catalytic activities of ICDH kinase/phosphatase constitute a moiety conserved cycle, require ATP, and exhibit 'zero-order ultrasensitivity' []. | Name | Isocitrate dehydrogenase kinasephosphatase |
Short Name | Isocitrate_DH_AceK | Type | Family |