| Description | BtrN catalyses an unusual radical mediated dehydrogenation during aminoglycoside biosynthesis: oxidation of 2-deoxy-scyllo-inosamine (DOIA) to amino-dideoxy-scyllo-inosose (amino-DOI) in the biosynthetic pathway of butirosin [ , ]. Butirosin is an amino cyclitol glycoside antibiotic produced byBacillus circulans, and bears a unique (S)-4-amino-2-hydroxybutyrate (AHBA) side chain. BtrN contains two [4Fe-4S] clusters, the first is the canonical radical SAM cluster, the second is implicated in substrate-radical oxidation (oxidises a secondary alcohol to a ketone). This family of proteins has a non-canonical structural architecture with a β5/α4 motif [, ]. | Name | 2-Deoxy-scyllo-inosamine dehydrogenase (BtrN-like) |
| Short Name | BtrN-like | Type | Family |
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