| Description | This entry identifies a family of at least two different sugar 1,4 lactone oxidases, both involved in synthesising ascorbic acid or a derivative. These include L-gulono-1,4-lactone dehydrogenase from bacteria ([intenz:1.1.2.-]), L-gulonolactone oxidase () from mammals and D-arabinono-1,4-lactone oxidase Alo1 ( ) from yeasts. Members are proposed to have the cofactor FAD covalently bound at a site specified by . This family also includes DprE1 from Mycobacterium, a component of the DprE1-DprE2 complex that catalyses the 2-step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose, a precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans [ ]. It catalyses the first step of epimerization which implies the oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose in a FAD-dependent manner []. | Name | L-gulonolactone/D-arabinono-1,4-lactone oxidase-like |
| Short Name | FAD_lactone_oxidase-like | Type | Family |
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