| Description | Medium-chain specific acyl-CoA dehydrogenases (MCADs) are mitochondrial beta-oxidation enzymes, which catalyse the alpha,beta dehydrogenation of the corresponding medium chain acyl-CoA by FAD, which becomes reduced [ , ]. The reduced form of MCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. MCAD is a homotetramer [, ]. This protein contribute to PINK1-mediated regulation of fatty acid and amino acid metabolism, through a mechanism that is independent of its acyl-CoA dehydrogenase activity. Mutations in PINK1 are associated with Parkinson's disease []. | Name | Medium-chain specific acyl-CoA dehydrogenase |
| Short Name | MCAD | Type | Family |
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