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Protein Domain : IPR036784

Description  Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. Regulating the activity of the branched-chain alpha-ketoacid dehydrogenase (BCDH) complex is the primary means by which these processes are coordinated. BCDH kinase regulates BCDH by phosphorylation, thereby inactivating it when synthesis is required.The N-terminal domain of the alpha-ketoacid dehydrogenase kinase has a bromodomain-like fold, which consists of four helices arranged in bundle with minor mirror variant of up-and-down topology. Name  Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
Short Name  AK/P_DHK_N_sf Type  Homologous_superfamily
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4 Protein Domain Regions