| Description | Succinate semialdehyde dehydrogenase (SSADH) is one of three enzymes constituting 4-aminobutyrate (GABA) degradation in both prokaryotes and eukaryotes, catalysing the (NAD(P)+)-dependent catabolism reaction of succinate semialdehyde to succinate for metabolism by the citric acid cycle. In Escherichia coli, SSADH is located in a unidirectionally transcribed gene cluster encoding enzymes for GABA degradation and is suggested to be co-transcribed with succinate semialdehyde transaminase from a common promoter upstream of SSADH [ ]. Similar gene arrangements can be found in characterised Ralstonia eutropha (Alcaligenes eutrophus) [] and the genome analysis of Bacillus subtilis.Prokaryotic SSADH enzymes ( ) share high sequence homology to characterised SSADH from rat and human ( ), exhibiting conservation of proposed cofactor binding residues, and putative active sites (G-237 and G-242, C-293 and G-259 respectively of rat SSADH) [ ]. | Name | Succinate semialdehyde dehydrogenase |
| Short Name | Succ_semiAld_DH | Type | Family |
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