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Protein Domain : IPR036714

Description  This superfamily includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE.Both yeast and human Sdh5/SDHAF2, which are mitochondrial succinate dehydrogenase assembly factors, interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans [ ]. Name  Flavinator of succinate dehydrogenase superfamily
Short Name  SDH_sf Type  Homologous_superfamily
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2 Publications

Genomics

2 Cross References

 

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1 Data Sets

0 Parent Features

14 Protein Domain Regions