| Description | This entry represents the GNAT domain found in PanZ.PanD is a l-aspartate alpha-decarboxylase involved in the biosynthesis of pantothenate, the precursor of coenzyme A (CoA). PanD is synthesised as pro-PanD, which undergoes auto-proteolytic cleavage to generate active PanD. PanM binds to and activates PanD by stabilising pro-PanD in an autocleavage-prone conformation [ ]. PanM acts as an acetyl-CoA sensor that can trigger the maturation of pro-PanD, but lacks acetyltransferase activity []. The regulation of PanD by PanZ allows enterobacterial species to closely regulate production of beta-alanine and hence pantothenate in response to metabolic demand []. Structure and function studies show that direct interaction of PanD with the PanZ Arg43-Leu46 loop promotes PanD to adopt a reactive conformation, which leads to activation []. | Name | PanZ, acetyltransferase (GNAT) domain |
| Short Name | PanZ_GNAT | Type | Domain |
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