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Protein Domain : IPR028882

Description  Succinate dehydrogenase assembly factor 2 (SDHAF2, also known as Sdh5 or Emi5) is required for insertion of FAD cofactor into SDH1, the catalytic subunit of succinate dehydrogenase (SDH) [ ]. SDH complex is a component of both the electron transport chain and the tricarboxylic acid cycle.This entry includes mitochondrial SDHAF2 from fungi and metazoans. In humans, mutations in SDHAF2 gene cause paragangliomas 2 (PGL2), which is a neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion [ ]. Name  Succinate dehydrogenase assembly factor 2, mitochondrial
Short Name  SDHAF2 Type  Family
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