Description | A member of this family has been identified in Staphylococcus aureus as a dehydrogenase involved in the synthesis of a new opine metallophore, named staphylopine. It is encoded as part of an operon that also includes an histidine racemase and an enzyme distantly related to nicotianamine synthase [ ]. Staphylopine is involved in metal acquisition, chelating nickel, cobalt, zinc, copper or iron, depending on the growing conditions. Metal acquisition is vital for bacteria growing in metal-scarce environments, such as inside a host in the case of pathogens.This family also includes similar synthases from Pseudomonas aeruginosa, and Yersinia pestis, which catalyse the final step in the biosynthesis of pseudopaline and yersinopine, respectively [ ]. | Name | Opine metallophore dehydrogenase |
Short Name | Opine_metallophore_DH | Type | Family |