| Description | In Saccharomyces cerevisiae, Met8 is a bifunctional dehydrogenase ( ) and ferrochelatase ( ) [ ]. It catalyses the final two steps in the biosynthesis of sirohaem, involving a NAD(+)-dependent dehydrogenation of precorrin-2 to generate sirohydrochlorin followed by ferrochelation to yield sirohaem []. Siroheme is a heme-like prosthetic group used by sulfite and nitrite reductases []. The structure of Met8 has been resolved. A single active site, Asp141, has been shown to play an essential role in both dehydrogenase and chelatase processes []. | Name | Siroheme biosynthesis protein Met8 |
| Short Name | Met8 | Type | Family |
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