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Protein Domain : IPR010047

Description  This entry describes the Ni-containing carbon monoxide dehydrogenase (CODH) family ( ). These enzymes reversibly oxidise CO to CO(2), and play key roles in the energy-yielding pathways of various autotrophic anaerobes, allowing these organisms to grow with CO as the sole carbon source [ ]. The active sites of these enzymes contain Ni-iron-sulphur (NiFeS) clusters. This family also includes the CODH subunit of bifunctional CODH/acetyl-CoA synthetase (CODH/ACS), which contains two Ni-containing active sites to catalyse the formation of acetyl-CoA from CO(2)-derived CO [, ].CODH is related to hybrid cluster proteins (HCP, or prismane) ( ), a complex whose activity is not yet fully described; the hybrid Fe-S cluster in HCPs is similar to the NiFeS cluster in CODH [ ]. Name  Ni-containing CO dehydrogenase
Short Name  CODH Type  Family
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Genomics

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