| Description | This entry includes ropporin-1A (ROP1A, also called cancer/testis antigen 91, CT91, or rhophilin-associated protein 1A), ropporin-1B (ROP1B, also called rhophilin-associated protein 1B), and ropporin-1-like protein (ROPN1L, also called ROPN1-like protein, AKAP-associated sperm protein, or ASP). ROP1A, ROP1B and ROPN1L play important roles in male fertility [ , , , ]. They are involved in fibrous sheath integrity and sperm motility and play roles in cAMP-dependent protein kinase (PKA)-dependent signaling processes required for spermatozoa capacitation. ROP1A and ROP1B have been shown to bind AKAP3 [, ].This entry represents a conserved helical bundle domain that shows high sequence similarity to the dimerization/docking (D/D) domain of the regulatory subunit of PKA, which dimerizes to form a four-helix bundle that serves as a docking site for A-kinase-anchoring proteins (AKAPs). It has been suggested that ROPN1 activates RhoA signalling via rhophilin-1 (RHPN1), promoting cell migration, invasion and metastatic potential. ROPN1A/B has been identified as antigens able to induce a strong humoral immune response, being possible targets for immunotherapy in certain cancers [ , ]. | Name | Ropporin, dimerization/docking domain |
| Short Name | ROP_DD | Type | Domain |
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