| Description | This entry represents the RNA recognition motif (RRM) of budding yeast Nrd1 and fission yeast Seb1. Nrd1 is a novel heterogeneous nuclear ribonucleoprotein (hnRNP)-like RNA-binding protein. It is part of the Nrd1-Nab3-Sen1 (NNS) complex that is involved in the termination and processing of short RNA polymerase II transcripts [ ].Nrd1 contains an RNA recognition motif (RRM), a short arginine-, serine-, and glutamate-rich segment similar to the regions rich in RE and RS dipeptides (RE/RS domains) in many metazoan splicing factors, and a proline- and glutamine-rich C-terminal domain (P+Q domain) similar to domains found in several yeast hnRNPs. Disruption of NRD1 gene is lethal to yeast cells. Its N-terminal domain is sufficient for viability, which may facilitate interactions with RNA polymerase II where Nrd1 may function as an auxiliary factor. By contrast, the RRM, RE/RS domains, and P+Q domain are dispensable [ ].Seb1 is an RNA-binding protein essential for cell viability and bound directly to Rpb7 subunit of RNA polymerase II. Seb1 does not function in NNS-like termination. Instead, Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection [ ]. It also contains one RRM motif and a region rich in arginine-serine dipeptides (RS domain) []. | Name | Nrd1/Seb1, RNA recognition motif |
| Short Name | Nrd1/Seb1_RRM | Type | Domain |
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