| Description | Proteins in this entry are required for type I protein secretion and have an N-terminal ABC transporter type 1 transmembrane domain and a C-terminal P-loop containing nucleoside triphosphate hydrolase domain. The transmembrane domain forms a pore in the inner membrane and the ATP-binding domain is responsible for energy generation. Sequences are mainly from bacteria, but there are homologues from eukaryotes and archaea. Proteins in this entry include the following:Lipid A export ATP-binding/permease protein MsbA, which is required for lipid A and possibly glycerophospholipid transport, and for biogenesis of the outer membrane in bacteria [ ] Beta-(1-->2)glucan export ATP-binding/permease protein NdvA from nitrogen-fixing bacteria, which is required for beta-(1-->2)glucan export, essential for nodule formation in legume roots [ ] Iron-sulfur clusters transporter ATM1, a yeast mitochondrial protein that exports Fe/S cluster-containing protein precursors and other mitochondrially synthesized proteins to the cytoplasm [ ]. The mammalian equivalents are the ATP-binding cassette sub-family B members 6, 7, 8 and 9, which are required for the transport of heme and porphyrin from the cytoplasm to the mitochondrion [] Leukotoxin translocation ATP-binding protein LktB, required for leukotoxin export in Mannheimia haemolyticaMultidrug resistance protein 1, which exports xenobiotics, such as cytotoxic drugs, out of cells leading to tumour cell resistance to multiple drugs [ ]. The bacterial equivalents include multidrug resistance-like ATP-binding protein MdlAAlpha-hemolysin translocation ATP-binding protein HlyB from E. coli, a component of the ABC transporter complex HlyBD required for the export of hemolysin [ ] Phosphatidylcholine translocator ABCB4, required for lipid secretion in the bile, transporting phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes [ ] Bile salt export pump, required for the secretion of bile salts into the canaliculus of hepatocytes [ ] Antigen peptide transporter 1, which is required for the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules [ ] P-glycoprotein 14 which exports polar lipids into the developing pharyngeal cuticle to protect against xenobiotic insult [ ]. PGP-14 has an internal duplication and two copies of the constituent domains. | Name | Type 1 protein exporter |
| Short Name | Type_1_exporter | Type | Family |
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