| Description | Bacterial type IV pili are surface filaments critical for diverse biological processes including surface and host cell adhesion, colonisation, biofilm formation, twitching motility, DNA uptake during natural transformation and virulence [ , ]. The proteins necessary to form the type IV pili inner-membrane complex, are included in the pilMNOPQ operon which encodes the cytoplasmic actin-like protein PilM, PilN, PilO, the periplasmic lipoprotein PilP and the outer-membrane secretin PilQ. The inner-membrane PilM/N/O/P complex is required for the optimal function of the outer-membrane secretin PilQ. This cluster is highly conserved across the type IV pilus-producing bacterial species, and all of these proteins have been shown to be essential for twitching motility [, ].The PilP family are periplasmic proteins involved in the biogenesis of type IV pili [ ]. The N-terminal domain of PilP interacts with the periplasmic regions of PilNO, while the C-terminal beta-domain of PilP interacts with the N0 domain of PilQ, connecting PilO to the secretin PilQ [].This entry also includes competence protein D (comD) from Haemophilus influenzae which is encoded in the homologous operon comA/B/C/D/E. | Name | Type IV pilus inner membrane component PilP |
| Short Name | PilP | Type | Family |
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