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Protein : MBD4L_ARATH A. thaliana

Primary Accession  ? Q0IGK1 Organism . Name  Arabidopsis thaliana
Length  445   MD5 Checksum  3279fb1371f4a570dc1ecd6ddc426a1e
UniProt Accession  Q0IGK1 Is UniProt Canonical  true
UniProt Name  MBD4L_ARATH Is Fragment  false
Molecular Weight  51135.0 Name  Methyl-CpG-binding domain protein 4-like protein
Secondary Identifier  Q0IGK1

5 Comments

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1 Genes

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1 Organism

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5 Publications

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Genomics

9 Cross References

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1 Genes

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Proteins

Curated comments from UniProt

Type Comment
function Monofunctional DNA glycosylase targeting U:G and T:G mispairs (PubMed:23994068). Excises uracil derivatives and exhibits a preference for a CpG sequence context, irrespective of the methylation status of the complementary strand (PubMed:23994068). The activity follows a biphasic kinetics, with an initial burst of product accumulation followed by a slower phase (PubMed:23994068). Specifically binds its reaction product (PubMed:23994068). Triggers the base excision repair (BER) pathway (PubMed:25900572).
tissue specificity Isoform 1 and isoform 4: Expressed in leaves and flowers, but not in roots or stems.

11 Features

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4 Isoforms

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6 Keywords

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2 Protein Domain Regions

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1 Sequence

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Other

0 Canonical Protein

0 Components

2 Data Sets

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1 Ec Numbers

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0 Locations