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Protein Domain : IPR010269

Description  The long cytoplasmic tubular structure of the T6SS system is wrapped by a sheath structure composed of two proteins, TssB and TssC. Contraction of the sheath causes the internal tube of the T6SS with associated effectors to be propelled out of the effector cell and across the membranes of bacterial or eukaryotic target cells [ , , ].TssB and TssC assemble into tubular structures with cogwheel patterns resembling the bacteriophage contractile sheath [ ]. Several structures of T6SS sheath assemblies have been solved displaying a helical assembly [, , ]. Interactions between TssB and TssC occur between the N-terminal region of TssC and the conserved a-helix of TssB []. The two proteins of the F. novicida T6SS outer sheath, IglA (TssB) and IglB (TssC), are interdigitated into a single fold similar to that of the phage sheath. The F. novicida T6SS outer sheath has a highly interlaced two-dimensional array architecture with augmented β sheets that is essential to secretory function [ ].Three distinct T6SS subtypes exist, T6SSi, in which most proteobacterial T6SSs are found, including V. cholerae and P. aeruginosa; T6SSii for the Francisella T6SS; and T6SSiii for Bacteroidetes systems [ ].TssB/TssC are also known as IglA/IglB and VipA/VipB.The type VI secretion system (T6SS) is a supra-molecular bacterial complex that resembles phage tails. It is a toxin delivery systems which fires toxins into target cells upon contraction of its TssBC sheath [ ]. Thirteen essential core proteins are conserved in all T6SSs: the membrane associated complex TssJ-TssL-TssM, the baseplate proteins TssE, TssF, TssG, and TssK, the bacteriophage-related puncturing complex composed of the tube (Hcp), the tip/puncturing device VgrG, and the contractile sheath structure (TssB and TssC). Finally, the starfish-shaped dodecameric protein, TssA, limits contractile sheath polymerization at its distal part when TagA captures TssA []. Name  Type VI secretion system TssC-like
Short Name  T6SS_TssC-like Type  Family
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Genomics

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