| Description | This entry represents the C-terminal domain of Bifunctional protein PutA from Escherichia coli [ ] and similar sequences predominantly found in proteobacteria. This domain corresponds to the aldehyde dehydrogenase activity (Delta-1-pyrroline-5-carboxylate dehydrogenase, ) of PutA, which is critical in the de novo biosynthesis of proline and ornithine. It is the rate-limiting enzyme in proline biosynthesis and is subject to feedback inhibition by proline. Structurally, this domain shows two lobes, one that binds NAD+ using a nonclassical Rossmann fold and another harbours the catalytic cysteine [ ]. | Name | Bifunctional protein PutA, C-terminal domain |
| Short Name | PutA_C | Type | Domain |
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