| Description | This superfamily represents a domain found in bacterial 5,10-methylenetetrahydrofolate reductases and eukaryotic Proline dehydrogenase 1 and Hydroxyproline dehydrogenases. It is also found at the N-terminal domain of the eukaryotic enzyme Methylenetetrahydrofolate reductase (NADPH) and the bacterial bifunctional protein putA.Both eukaryotic and prokaryotic methylenetetrahydrofolate reductases generate 5-methyltetrahydrofolate from 5,10-methylenetetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine [ , ]. In humans, there are several clinically significant mutations in MTHFR that result in hyperhomocysteinemia, which is a risk factor for the development of cardiovascular disease []. | Name | FAD-linked oxidoreductase-like |
| Short Name | FAD-linked_oxidoreductase-like | Type | Homologous_superfamily |
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