| Description | This entry represents cell wall amidases, including domesticated amidase effector 2 (Dae2) from ticks and type VI amidase effector 2 (Tae2, also known as BTH_I0068 ) from bacteria [ , ]. Dae2 has been horizontally acquired from bacteria and has structurally and biochemically diverged from its ancestral bacterial counterparts, leading to broadened antimicrobial specificity [ , ].Dae2 is a gut and saliva antibacterial peptide that directly antagonizes host skin commensals which enter the ticks during feeding [ ]. It acts as a cell wall hydrolase that cleaves the bond between gamma-D-glutamate-meso-diaminopimelate of a peptide stem and D-alanine of another peptide stem in peptidoglycans [].These proteins are predicted to fold into an open β-barrel with SH3-like topology. | Name | Cell wall amidase Dae2/Tae2-like |
| Short Name | Dae2/Tae2-like | Type | Family |
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