| Description | This family of bacterial proteins includes cell division inhibitor MciZ from Bacillus subtilis. MciZ is required during sporulation, blocking Z-ring formation in the mother cell by inhibiting the polymerization of FtsZ [ ]. FtsZ (filamentation temperature-sensitive Z) is the bacterial homologue of tubulin. Crystal structure reveals that MciZ binds to the C-terminal polymerization interface of FtsZ, the equivalent of the minus end of tubulin, causing shortening of protofilaments and blocking the assembly of higher-order FtsZ structures. Hence, MciZ provides a capping-based regulatory mechanism for FtsZ []. | Name | Cell division inhibitor MciZ |
| Short Name | MciZ | Type | Family |
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