| Description | Programmed cell death protein 1 (PDCD1), also known as PD1, is an immune-checkpoint receptor mainly expressed by T cells that negatively regulates immune response [ ]. It interacts with its ligands PD-L1 and PD-L2 to inhibit T cell effector functions in an antigen-specific manner []. The PD1-mediated inhibitory pathway is exploited by some tumours to attenuate anti-tumour immunity and escape destruction by the immune system []. | Name | Programmed cell death protein 1 |
| Short Name | PDCD1 | Type | Family |
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