Description | This entry represents the forkhead (FH) domain of human FOXQ1 and similar sequences mainly found in vertebrates. The FH domain is a winged helix DNA-binding domain.Forkhead box protein Q1 (FOXQ1), also called HNF-3/Forkhead-like protein 1 (HFH-1), or hepatocyte nuclear factor 3 Forkhead homolog 1, plays a role in hair follicle differentiation. It has also been reported to promote epithelial differentiation, inhibit smooth muscle differentiation, activate T cells and autoimmunity, and control mucin gene expression and granule content in stomach surface mucous cells [ , , , , , ]. FOXQ1 is significantly associated with the pathogenesis of various tumour types including gastric, breast, colorectal, pancreatic, bladder and ovarian cancer, and glioma [, , , , ]. | Name | Forkhead box protein Q1, forkhead domain |
Short Name | FH_FOXQ1 | Type | Domain |