| Description | JAM-C (also known as JAM3) is an adhesion molecule expressed by endothelial cells (ECs) that plays a role in tight junction formation, leukocyte adhesion, and transendothelial migration [ , ]. Platelet JAM-C has been find to bind neutrophil integrin alphaMbeta2 (Mac-1/CD11b/CD18) to help neutrophils to transmigrate through endothelium []. Mutations in the JAM-C gene cause haemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts [].Junctional Adhesion Molecules (JAMs), including JAM-A/B/C, are a subset of the immunoglobulin superfamily, which have two extracellular immunoglobulin-like domains, a cytoplasmic tail and a PDZ-domain-binding motif [ ]. They can form homodimers at the surface of one cell and between two neighbouring cells and heterodimers can also occur between JAM-B and JAM-C. They can also interact with human leukocyte integrins []. | Name | Junctional adhesion molecule C |
| Short Name | JAM-C | Type | Family |
Powered by
Have you tried our InterMine mobile apps?
and interoperation is funded by 
