| Description | The YjgF/YER057c/UK114 family (also known as the Rid family) of proteins is conserved in all domains of life [ ]. A phylogenetic analysis applied by Lambrecht et al.has divided the Rid family into a widely distributed archetypal RidA (YjgF) subfamily and seven other subfamilies (Rid1 to Rid7) that are largely confined to bacteria and often co-occur in the same organism with RidA and each other [ ]. Although the family members share high levels of protein sequence and structure similarity, their functions vary widely across different species [].Structurally, these proteins are homotrimers with clefts between the monomeric subunits that are proposed to have some functional relevance [ , , ].This family includes:YjgF (also known as RidA or 2-iminobutanoate/2-iminopropanoate deaminase), which displays enamine/imine deaminase activity and can accelerate the release of ammonia from reactive enamine/imine intermediates of the pyridoxal 5'-phosphate-dependent threonine dehydratase (IlvA) [ , ] the yeast growth inhibitor YER057c (protein HMF1) that appears to play a role in the regulation of metabolic pathways and cell differentiation [ ] the mammalian 14.5kDa translational inhibitor protein UK114, also known as L-PSP (liver perchloric acid-soluble protein), with endoribonucleolytic activity that directly affects mRNA translation and can induce disaggregation of the reticulocyte polysomes into 80 S ribosomes [ ] RutC from E. coli, which is essential for growth on uracil as sole nitrogen source and is thought to reduce aminoacrylate peracid to aminoacrylate [ ] YabJ from B. subtilis, which is required for adenine-mediated repression of purine biosynthetic genes [ ] Structurally, these proteins are homotrimers with clefts between the monomeric subunits that are proposed to have some functional relevance [ , , ].This family includes:Bacterial YjgF (also known as RidA or 2-iminobutanoate/2-iminopropanoate deaminase), which displays enamine/imine deaminase activity and can accelerate the release of ammonia from reactive enamine/imine intermediates of the pyridoxal 5'-phosphate-dependent threonine dehydratase (IlvA) [ , ] The yeast growth inhibitor YER057c (protein HMF1) that appears to play a role in the regulation of metabolic pathways and cell differentiation [ ] The mammalian 14.5kDa translational inhibitor protein or UK114 antigen homologue, also known as L-PSP (liver perchloric acid-soluble protein), which has been reported to show endoribonucleolytic activity that directly affects mRNA translation and can induce disaggregation of the reticulocyte polysomes into 80 S ribosomes [ ] and be responsible for the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism [, ] RutC from E. coli, which is essential for growth on uracil as sole nitrogen source and is thought to reduce aminoacrylate peracid to aminoacrylate [ ] YabJ from B. subtilis, which is required for adenine-mediated repression of purine biosynthetic genes [ ] | Name | YjgF/YER057c/UK114 family |
| Short Name | YjgF/YER057c/UK114 | Type | Family |
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