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Protein Domain : IPR045832

Description  This entry represents the cell cycle link protein Clink from Banana bunchy top virus (BBTV) [ ], which was identified as a suppressor of RNA silencing. It interacts with retinoblastoma-related proteins (pRB) and S-phase kinase-associated protein 1 (SKP1). Clink contains LxCxE and F-box motifs that mediate the interactions with the respective proteins and the capacity of Clink to bind pRB correlates with its ability to stimulate viral replication. pRB is a key cell cycle regulator, which represses onset and progression into S-phase by interacting with a wide range of cell cycle-related proteins. Name  Cell cycle link protein Clink
Short Name  Clink Type  Family
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