| Description | VP16 is a component of virion tegument layer that is required for the transcription of the viral immediate-early (IE) genes. In case of human herpes simplex virus (HSV) infection, VP16 binds to HCF-1 (host cell factor 1) and translocates to the nucleus to form a complex with the POU domain protein Oct-1. This complex then directs high level IE gene transcription by the potent activation domain in the C terminus of VP16. HCF-1 provides two functions required by VP16, complex assembly and nuclear targeting [ ]. | Name | Host cell factor C1 regulator 1 |
| Short Name | HCFC1R1 | Type | Family |
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