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Protein Domain : IPR004474

Description  This entry describes a domain (known as LCP domain) that is found in the predicted extracellular domain of a number of proteins involved in cell wall biosynthesis [ ]. One of these is protein Psr, described as a penicillin binding protein 5 (PDP-5) synthesis repressor. Another is Bacillus subtilis LytR, described as a transcriptional attenuator of itself and the LytABC operon, where LytC is N-acetylmuramoyl-L-alanine amidase. A third is CpsA, a putative regulatory protein involved in exocellular polysaccharide biosynthesis. These proteins share the property of having a short putative N-terminal cytoplasmic domain and transmembrane domain forming a signal-anchor []. Studies in Corynebacterium glutamicum revealed that this domain contains conserved aspartate and arginine residues and mutations in this domain are detrimental for the bacterium growth []. Name  Cell envelope-related transcriptional attenuator domain
Short Name  LytR_CpsA_psr Type  Domain
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