| Description | This entry represents the entire MarR-like, BRCT and chromo domains module found in SWI/SNF complex subunit SMARCC1 and subunit SMARCC2.Mammalian SWI/SNF (mSWI/SNF) of BAF complexes are a subfamily of SWI/SNF ATP-dependent chromatin remodellers that dynamically modulate chromatin structure to regulate fundamental cellular processes including gene transcription, cell cycle control, and DNA damage response [ ]. The BAF155/SMARCC1 subunit is a component of all complexes identified to date, incorporated either as a homodimer or as a heterodimer with its paralogue BAF170/SMARCC2. The BAF155 subunit predominates in stem cells, while the BAF170 subunit is incorporated during differentiation. The N-terminal of the BAF155/SMARCC1 and BAF170/ SMARCC2 subunits contain a putative DNA-binding MarR-like domain, achromo domain and a BRCT domain that are interconnected to each other to form a distinct module. This N-terminal module could participate in an interaction involving both protein and nucleic acid components [].The MarR-like domain forms a four-helix-bundle that resembles the MarR-like helix-turn-helix domain. The BRCT domain contains an inserted chromo domain between the second and third strands of the canonical fold. The chromo domain consists of the curved antiparallel three-stranded β-sheet characteristic of this domain. The individual domains are linked via a network of hydrogen bonds to form a single structural unit (}. The architecture of the fold produces a cleft containing two deep pockets at the interface between the domains [ ]. | Name | MarR-like, BRCT and chromo domains module |
| Short Name | MARR_BRCT_CHROMO | Type | Domain |
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