| Description | Tumor necrosis factor receptor superfamily member 3 (TNFRSF3, also known as lymphotoxin beta receptor, LTbetaR, CD18, TNFCR, TNFR3, D12S370, TNFR-RP, TNFR2-RP, LT-BETA-R, TNF-R-III) plays a role in lipid metabolism, immune response, programmed cell death, and in signaling during development of lymphoid and other organs [ , ]. Its ligands include lymphotoxin (LT) alpha/beta membrane form (heterotrimer) and tumor necrosis factor ligand superfamily member 14 (also known as LIGHT) []. TNFRSF3 agonism by these ligands initiates canonical, as well as non-canonical nuclear factor-kappaB (NF-kappaB) signaling, and preferentially results in the translocation of p52-RELB complexes into the nucleus []. While these ligands are often expressed by T and B cells, TNFRSF3 is conspicuously absent on T and B lymphocytes and NK cells, suggesting that signaling may be unidirectional for TNFRSF3 []. Activity of this receptor has also been linked to carcinogenesis; it helps trigger apoptosis and can also lead to release of the interleukin 8 (IL8) [, ]. Alternatively spliced transcript variants encoding multiple isoforms have been observed.This entry represents the N-terminal domain of TNFRSF3. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [ , , ]. | Name | Tumour necrosis factor receptor 3, N-terminal |
| Short Name | TNFRSF3_N | Type | Domain |
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