| Description | This entry represents the NADP binding domain of saccharopine dehydrogenase. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase [ , ].Saccharopine dehydrogenase ( ) catalyses the condensation of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, which is reduced by NADPH to give saccharopine [ ]. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase (PF). Saccharopine dehydrogenase can also function as a saccharopine reductase. Saccharopine is an intermediate in lysine metabolism.Homospermidine synthase (HSS) ( ) catalyses the synthesis of the polyamine homospermidine from 2 putrescine molecules in an NAD +-dependent reaction [ ]. HSS evolved from the alternative spermidine biosynthetic pathway enzyme carboxyspermidine dehydrogenase [ , ] and the structure of HSS is related to lysine metabolic enzymes []. | Name | Saccharopine dehydrogenase, NADP binding domain |
| Short Name | Sacchrp_dh_NADP | Type | Domain |
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