| Description | The absence of free iron molecules in the surrounding environment triggers transcription of gene clusters that encode both siderophore-synthesis enzymes, and receptors that recognise iron-bound siderophores [ ]. Classic examples are the enterobactin/enterochelin clusters found in Escherichia coli and Salmonella, although similar moieties in other pathogens have been identified. The enzymic machinery that produces vibrionectin in Vibrio cholerae is such a homologue [].EntA, a 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase enzyme, is the third enzyme in the biosynthesis of 2,3-dihydroxybenzoic acid (DHB) from chorismate in Escherichia coli. It converts isochorismate to DHB, used for the synthesis of iron chelator enterobactin. Bacillus subtilis possesses similar genes involved in siderophore biosynthesis [ ]. Deletion studies involving EntA-mutants have shown that it is essential for virulence []. | Name | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase |
| Short Name | DHB_DH | Type | Family |
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