| Description | This entry represents the WIV domain [ ] of Nonstructural protein NS-S from the tospovirus Tomato spotted wilt virus and related sequences from related Bunyavirales. Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase. Tospoviruses infect plants and arthropods (such as thrips), which serve as vectors for plant transmission.NS-S, present in infected cells, but absent from purified virus particles [ , ], is not essential for virus replication, but contributes substantially to pathogenesis []. It has been shown to inhibit the production of alpha/beta interferons, and to inhibit interferon regulatory factor-mediated cell death [, ]. It is a viral suppressor of host RNAi and viral inducer of host attractiveness to insect vectors. NSS acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing, a mechanism of plant viral defence that limits the accumulation of viral RNAs [, ]. The WIV domain probably facilitates viral infection of arthropods. WIV stands for 'Widespread, Intriguing, Versatile'. | Name | Nonstructural protein NS-S, WIV domain, bunyaviral |
| Short Name | NS-S_WIV_bunyaviral | Type | Domain |
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