Description | DesII is a member of the radical S-adenosyl-L-methionine (SAM) enzyme superfamily involved in the biosynthesis of TDP-D-desosamine. D-Desosamine is found in a number of macrolide antibiotics produced by Streptomyces venezuelae [ ]. DesII catalyses the deamination of TDP-4-amino-4,6-dideoxy-d-glucose to form TDP-3-keto-4,6-dideoxy-d-glucose [, ]. It can act as a deaminase or a dehydrogenase depending on the nature of its TDP-sugar substrate []. | Name | dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase |
Short Name | DesII | Type | Family |