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Protein Domain : IPR001534

Description  Transthyretin-related proteins form a nematode-specific expanded protein family that comprises 59 members, 54 of which are predicted to be secreted. The proteins show weak similarity to transthyretin (formerly called prealbumin) which transports thyroid hormones. [ ]. Some transthyretin-related genes are induced in response to environmental challenges such as oxidative stress or pathogen exposure. These proteins possess 4 cysteine residues that are conserved within the C. elegans transthyretin-related protein family, which could serve as reactive oxygen sensors or scavengers [].Transthyretin-related protein 52 (TTR-52), a member of this family, is required for efficient cell corpse engulfment by the recognition the surface exposed phosphatidylserine (PS). TTR-52 mediates recognition of apoptotic cells by cross-linking the PS signal with the phagocyte receptor CED-1 [ ]. Name  Transthyretin-like
Short Name  Transthyretin-like Type  Family
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3 Publications

Genomics

2 Cross References

 

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1 Data Sets

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