| Description | Peroxisome biogenesis factor 2 and 10, also known as peroxin-2/10 are involved in the formation of peroxisomes and matrix protein import. Tey form a retrotranslocation channel together with PEX12, which mediates the export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling [ , , ]. Each subunit contributes transmembrane segments that coassemble into an open channel. PEX2 is also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis []. | Name | Peroxisome biogenesis factor 2/10 |
| Short Name | PEX2/10 | Type | Family |
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