| Description | V-set and Ig domain-containing 4 (VSIG4) is a strong negative regulator of T cell proliferation and IL-2 production [ ]. It also negatively regulates macrophage activation by activating the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, reduction in mitochondrial reactive oxygen species secretion, and macrophage inhibition []. | Name | V-set and immunoglobulin domain-containing protein 4 |
| Short Name | VSIG4 | Type | Family |
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